Before we get into removing your unwanted American Express card from online login we should talk about options for closing your account online. The easiest way to close an Amex account, without having to call in, is to use Amex Chat. You can typically find the Amex Chat point on the right side of any runner while logged into your account. Just click on the bubble and tell them you would like to cancel the account. They can take care of everything right also and there.